Acquired Reactive Perforating Collagenosis treatment

Tips

• It has been observed to be associated with multiple disorders, including diabetes mellitus, renal failure, hyperparathyroidism, liver disease, neurodermatitis, IgA nephropathy, peri ampullary carcinoma with jaundice, adenocarcinoma and liver neoplasms.
• Search and manage the underlying causes.
• Urea, creatinine, FBG and glycosylated hemoglobin should be ordered.
• Histopathogical examination.

Medical treatment options

Topical

• Topical retenoid: Tretinoin 0.1%, Tazarotene 0.1% gel.
• Topical corticosteroids : Clobetasol propionate 0.05 % ointment.
• keratolytics : Salicylic acid.

Systemic

• Antihistamines
• Allopurinol: 100 mg once daily.
• Acitretin :25 mg daily.
• Prednisolone.
• isotretinoin. 
• Doxycycline: 100 mg daily.
• Oral hydroxychloroquine : 200 mg daily.
• Oral glycyrrhizin.

Physical treatment options

• NB-UVB : three times per week.
• PUVA: four times per week.
• Cryotherapy.
• Photodynamic therapy.
• Transcutaneous electrical nerve stimulation(case report)

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