Tips
- Screening for infections.
- Discontinue causative drug.
- Antiviral therapies for hepatitis B virus.
- Local wound care.
Medical treatment
For classic Polyarteritis Nodosa(PAN)
- Corticosteroids : 1 mg/kg/day of prednisone followed by tapering over 3–6 months.
For refractory cases or have internal organ affection
- Cyclophosphamide to be added for up to 12 months.
For cutaneous PAN
- Topical or intralesional corticosteroids may resolve localized areas of cutaneous involvement.
- Penicillin for for treatment and prophylaxis in children with cPAN.
Other options
- Methotrexate : 7.5–20 mg/week.
- Mycophenolate mofetil.
- Pentoxifylline.
- Intravenous immunoglobulin.
- Warfarin.
- Rituximab in refractory disease.
- Symptomatic treatment : NSAIDs.
For patients with hepatitis B‐associated PAN, the recommendation is to start with high‐dose corticosteroids for 2 weeks, followed by antiviral treatment and plasma exchange supervised by a hepatologist at a specialist center.